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You will likely be using water cooled centrifugals in this range as they will be very efficient, and have a good life. Two 300ton chillers will probably be a better base option, and serve the full building load without needing the lower efficiency pony chiller mentioned above. What you do from here entirely depends on the class of office building, low load and time spent at reduced load, which relates to climate and patterns of use: * VFD's are becoming very affordable and almost de rigour(outside of the tropics, where you may not have sufficient wet bulb suppression to make them worthwhile). * Long periods of low load operation may necessitate a smaller pony chiller, and the size of this will come from your load trends for the whole cooling season, otherwise you might get away with the turndown/Hot Gas Bypass on your base chillers. * Some applications - occupant requirements or long cooling season for example - may make a third redundant 300ton chiller worthwhile.